College of Dentistry | University of Florida

Dr. Ikramuddin Aukhil

Dr. Ikramuddin Aukhil

Periodontics

Professor & Chairman

Phone: 352-273-8360
E-mail: iaukhil@dental.ufl.edu
10-6D
P.O. Box 100434
Gainesville, Florida 32610-0434

  • M.S., Periodontics, University of Michigan, 1981
  • B.D.S., Dental Surgery, Bangalore University, 1976

Previous Positions/Projects

  • Professor, Department of Periodontology, School of Dentistry, UNC Chapel Hill, NC 27599 (1994-2005)
  • Visiting Research. Fellow, Dept. of Molecular Biology, Princeton University, Princeton, NJ (1996-1996)
  • Visiting Research Assoc. Professor, Dept. of Cell Biology, Duke Univ. Med. Ctr., Durham, NC (1988-1989)

Selected Publications

  • Aukhil, I.; Slemp, C.C.; Lightner, V.; Nishimura, K.; Briscoe, G. and Erickson, H.P.: Purification of Hexabrachion (Tenascin) from culture conditioned medium, and separation from a cell adhesion factor. Matrix 10:98-111, 1990.
  • Murphy-Ullrich, J.E.; Lighner, V.; Aukhil, I.; Yan, Y,; Erickson, H.P. and Hook, M.: Focal adhesion integrity is down-regulated by the alternatively spliced domain of human tenascin. J. Cell Biol. 115:1127-1136, 1991.
  • Aukhil, I.: Biology of tooth-cell adhesion. Dental Clinics of North America 35: No. 3, July 1991.
  • Aukhil, I. and Erickson, H.P.: Transfected BHK cells and transgenic mice expressing specific splice variants of tensascin. Mol. Biol. Cell Vol. 3, #740, 1992.
  • Leahy, D.; Hendrickson, W.; Aukhil, I. and Erickson, H.P.: Structure of a fibronectin type-III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science 258:987-991, 1992.
  • Aukhil, I.; Joshi, P.; Yan, Y. and Erickson, H.P.: Cell- and heparin-binding domains of the hexabrachion arm identified by Tenascin expression proteins. J. Biol. Chem. 268:2542-2553, 1993.
  • Joshi, P.; Chang, C.Y.; Aukhil, I. and Erickson, H.P.: Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. J. Cell Science 106:389-400, 1993.
  • Leahy, D.; Erickson, H.P.; Aukhil, I.; Joshi, P. and Hendrickson, W.: Crystallization of a fragment of human fibronectin: Introduction of methionine by site-directed mutagenesis to allow phasing via selenomethione. Proteins 19:48-54, 1994.
  • Uoshima, M.; Yan, Y. and Aukhil, I.: EIIB domain of human fibronectin may be enhancing cell adhesion. Mol. Biol. Cell #308, 1994 (abstract).
  • Paranko, J.; Kaipia, A.; Chiqnet-Ehrismann, R.; Aukhil, I. and Kusisito, M.: Sex-specific expression of tenascin C in fetal rat testis and ovary. Differentiation 58:329-339, 1995.
  • Aukhil, I.; Sahlberg, C. and Thesleff, I.: Basal layers of epithelium expresses tenascin in RNA during healing of incisional skin wounds. J. Periodont. Res. 31:105-112, 1996.
  • Leahy, D.; Aukhil, I. and Erickson, H.P.: 2.0 crystal structure of a fragment of human fibronectin encompassing the 7th through the RGD-containing 10th type III repeats. Cell 84:155-164, 1996.
  • Lin, T.H.; Aplin-A,E.; Shen, Y.; Chen, D.; Schaller, M.; Romer, L.; Aukhil, I. and Luliano, R.L.: Integrin-mediated activation of MAP kinase is independent of FAK: Evidence for dual integrin signalling pathways in fibroblasts. J. Cell. Biology 136:1385-1395, 1997.
  • Uoshima, M., Yan, Y., Schnieder, G. and Aukhil, I.: The alternatively spliced domains EIIIB and EIIIA of human fibronectin affect cell adhesion and spreading. J. Cell Science 110:2271-2280, 1997.
  • Hupp, J.G.; Trope, J.; Mesaros, S.V. and Aukhil, I.: Initiated thymidine uptake in periodontal ligament of dogs teeth stored in various media for extended time periods. Endodontics & Dental Traumatology 13:223-227, 1997.
  • Aukhil, I.: Biology of wound healing. Periodontology 22:44-50, 2000.
  • Sahlberg, C.; Aukhil, I. and Thesleff, I.: Tenascin-C in developing murine teeth: Expression of splice variants and induction by TGFº-1 and FGF. Eur. J. Oral Sci. 109:116-124, 2001.
  • Cui,CCB., Cooper,LF., Yang,X., Karsenty, G. and Aukhil,I. Transcriptional co-activation of bone-specific transcription factor Cbfa1 by TAZ. Mol.Cell. Biol. 23:1004-1013, 2003.
  • Dekok,I., Peter,SJ., Archambault,M., van den Bos,C., Kadiyala,S., Aukhil,I. and Cooper,LF. Investigation of allogeneic mesenchymal stem cell-based alveolar bone regeneration: Preliminary findings. Clinical & Oral Implantology Research 14: 481-489, 2003.
  • Aukhil,I. Molecular Factors in Periodontal wound healing. J. de Parodonologie & d'Implantologie Orale 23: 29-42, 2004.
  • Bencharit S, Cui CB, Siddiqui A, Howard-Williams EL, Sondek J, Zuobi- Hasona K, & Aukhil I. Structural insights into fibronectin type III domain-mediated signaling. J Mol Biol. 2007 Mar 23; 367(2):303-9.
  • Koutouzis, T., D. Haber, L. Shaddox, I. Aukhil, and S. M. Wallet. Reactivity of serum total Ig Antibodies to Periodontal Host Tissue Components: A Pilot Study. Journal of Periodontology. 80:625-633, 2009.
  • Shaddox, L., J. Wiedey, E. Bimstein, I. Magnuson, M. Clare-Salzler, I. Aukhil, and S. M. Wallet. Hyper-Responsive Phenotype in Localized Aggressive Periodontitis. J. Dent. Res. 89: 143-148, 2010.

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